Summary of in vivo studies of the effectiveness of TMMEP. The “Model” column indicates the model chosen as well as the type and number of cells used for tumor induction. The “Particle injection” column first indicates the time of injection of the particles, defined as a day (Day 0 corresponding to tumor induction) or depending on the diameter D of the tumor; then indicates the quantity of particles injected as well as the injection procedure. The “Molecules” column indicates the complementary molecules used. The “Magnetic field” column indicates the first time of exposure, defined as a specific day or depending on the volume V of the tumor or a delay after NP injection. The duration of exposure to the field and possible repetitions are then indicated. The “Study” column indicates the time of sampling, often defined as a duration after magnetic field exposure (MFE) as well as the methods used to evaluate the effectiveness of the TMMEP. The abbreviation HE stands for hematoxylin–eosin labelling.

Ref.	Model	Particle injection		Molecule	Magnetic field		Analysis
		Timing	Procedure		Beginning	Duration	Timing	Procedure
Cho et al., 2012 (ref. 42)	Zebrafish	Day 0	2.5 ng injected in the vitellus		24 h after NP	24 h	Immediately after MFE	Tail angle, apoptosis
Y. Cheng et al., 2015 (ref. 37)	Athymic nude mice 1 × 105 U87 cells in orthotopic model (brain)	Day 0	50 NP/cell injected with cells		From day 4	1 h × 7 days	Along study	Survival study, tumor volume monitoring via luciferase
		Day 3	5 × 106 NP injected intra-tumoraly		From day 4	1 h × 7 days	Immediately after MFE	Apoptosis observation, HE label
Zamay et al., 2016 (ref. 40)	ICR white mouse 1 × 106 EAC cells in the leg	Day 7	2 × 107 NP/100 μl PBS injected intra-tumoraly	AS-9 and AS-14	1 h after NP	10 min	4 h after MFE	HE label
Vegerhof et al., 2016 (ref. 49)	Nude mice 2 × 106 A431 cells subcutaneous	D > 4–5 mm	6 mg of NP in 200 μl injected intravenously	Cetuximab	2 h after NP	30 min × 7 in 14 days	Week 3	Tumor volume monitoring
Brossel et al., 2016 (ref. 47)	BALB/C mice 1 × 107 MDA-MB-231 cells subcutaneous	Day 0	5 mg of iron injected with cells		V > 0.1–0.2 cm3	2 h × 21 days	Different timing	Tumor volume monitoring, HE label
Li et al., 2017 (ref. 50)	C75BL/6 mice 1 × 105 MCF-7 cells subcutaneous	D > 5 mm	2 mg of NP (in average) injected subcutaneously		8 h after NP	1 h	24 h after MFE	HE label
M. Chen et al., 2020 (ref. 25)	Athymic nude mice 5 × 106 U87 cells subcutaneous	Day 0, 2 and 4	5 mg kg−1 of NP injected intra-tumoraly		From day 1	30 min × 6 in 14 days	Day 21	Tumor volume monitoring, apoptosis observation, HE label
	Athymic nude mice 2 × 106 U87 cells in orthotopic model (brain)	Day 0	2.5 mg kg−1 of NP injected intra-tumoraly		From day 2	20 min × 5 days	Along study	Survival study, HE label