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. 2022 Aug 27;22:323. doi: 10.1186/s12883-022-02848-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — The proportion of eyes with reduced RNFL in each quadrant (MOGAD-ON and AQP4-ON). Compared with the manufacturer’s specification data, MOGAD-ON eyes with reduced thickness of RNFL in different quadrants accounted for 62–88%. AQP4-ON eyes with reduced thickness of RNFL in different quadrants accounted for 58–83%. The proportion of MOG-ON eyes had reduced RNFL thickness in the superior-temporal and temporal-superior regions, which were significantly higher than that of AQP4-ON eyes (58–63%, p = 0.004 in temporal-superior area, p = 0.001 in superior-temporal area). AQP4-ON: Aquaporin4-IgG seropositive optical neuritis, MOGAD-ON: MOG-Ab-associated disease optical neuritis, TS: temporal-superior quadrant; ST: superior-temporal quadrant; SN: superior-nasal quadrant; NS: nasal-superior quadrant; NS: nasal-superior quadrant; IN: inferior-nasal quadrant; NI: nasal-inferior quadrant; IT: inferior-temporal quadrant; TI: temporal-inferior quadrant