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. 2022 Aug 27;22:928. doi: 10.1186/s12885-022-09926-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Association between lnc-HOXB8-1:2 and CXCR3 in TAMs. A, The rising expression of CXCR3 and lnc-HOXB8-1:2 in TAMs (stained by CD68) that infiltrated neuroendocrine differentiated CRC tissue specimens showed by successive tissue sections. Scale bar =100μm and 20 μm. B-D, The expression of CD68, lnc-HOXB8-1:2 and CXCR3 in the NED group were significantly upregulated. E, Correlation analysis found that a significant positive correlation existed between CD68 and lnc-HOXB8-1:2, CXCR3 and CD68, CXCR3 and lnc-HOXB8-1:2. F, qRT–PCR assay revealed an increase of lnc-HOXB8-1:2 in TAMs cocultured with CgA Exo. *, P < 0.05; **, P < 0.01; ***, P < 0.001; TAMs, tumor-associated macrophages; NC, negative control; NED, neuroendocrine differentiation; non-NED, non-neuroendocrine differentiation; CgA, chromogranin A; Exo, exosomes