Table 1.

CTV, PTV and OARs objectives implementation in the RapidPlan model

Structure	Constraint type	Volume	Dose	Priority
PTV and CTV	Upper	0%	101%	Generated
	Lower	100%	99.0%	Generated
Lungs	Upper	20%	Generated	Generated
	Mean	–	Generated	Generated
	Line	Generated	Generated	Generated
Breasts	Upper gEUD	35.0 (#)	Generated	Generated
	Upper gEUD	1.0 (#)	Generated	Generated
	line	Generated	Generated	Generated
Heart	Upper gEUD	35.0 (#)	Generated	Generated
	Upper gEUD	1.0 (#)	Generated	Generated
	line	Generated	Generated	Generated
Oesophagus	Upper gEUD	35.0 (#)	Generated	Generated
	Upper gEUD	1.0 (#)	Generated	Generated
	line	Generated	Generated	Generated
Stomach	Upper gEUD	35.0 (#)	Generated	Generated
	Upper gEUD	1.0 (#)	Generated	Generated
	line	Generated	Generated	Generated
Bowel bag	Upper gEUD	35.0 (#)	Generated	Generated
	Upper gEUD	1.0 (#)	Generated	Generated
	line	Generated	Generated	Generated
Kidneys	Upper gEUD	35.0 (#)	Generated	Generated
	Upper gEUD	1.0 (#)	Generated	Generated
	line	Generated	Generated	Generated
Spinal cord	Upper gEUD	35.0 (#)	Generated	Generated
	Upper gEUD	1.0 (#)	Generated	Generated
	line	Generated	Generated	Generated
Liver	Upper gEUD	35.0 (#)	Generated	Generated
	Upper gEUD	1.0 (#)	Generated	Generated
	Upper gEUD	Generated	Generated	Generated
Spleen	Upper gEUD	35.0 (#)	Generated	Generated
	Upper gEUD	1.0 (#)	Generated	Generated
	line	Generated	Generated	Generated

Heart, breasts, stomach, kidneys, liver and spleen were modelled and trained separately if ipsi- or if contra-lateral. For the lungs, only the contralateral volume was considered

CTV: clinical target volume; PTV: planning target volume; gEUD: generalized equivalent uniform dose; (#) the α parameter of gEUD; α  = 1 correspond to the mean dose while α  = 35 acts on the high dose region, in proximity of the near-to-maximum dose