Table 1.
Baseline characteristics of 354 people with compensated NAFLD cirrhosis included in the study.
| Overall n = 354 | Without prior decompensations n = 271 | With prior decompensations n = 83 | p value | |
|---|---|---|---|---|
| Age, mean years (SD) | 67.3 (9.6) | 66.9 (9.2) | 68.8 (10.5) | 0.11 |
| Females, n (%) | 171 (48.3) | 132 (48.7) | 39 (47.0) | 0.78 |
| Tobacco use, n (%) | 38 (10.8) | 27 (10.1) | 11 (13.3) | 0.41 |
| Alcohol use, n (%)∗ | 76 (21.5) | 60 (22.1) | 16 (19.3) | 0.57 |
| BMI, median kg/m2 (IQR) | 31.2 (27.6-35.1) | 31.8 (27.8-35.3) | 30.2 (26.9-32.9) | 0.023 |
| BMI ≥25 kg/m2, n (%) | 302 (92.9) | 240 (94.1) | 62 (88.6) | 0.10 |
| BMI ≥30 kg/m2, n (%) | 188 (57.8) | 150 (58.8) | 38 (54.3) | 0.49 |
| Arterial hypertension, n (%) | 251 (70.9) | 193 (71.2) | 58 (69.9) | 0.81 |
| T2D, n (%) | 258 (72.9) | 196 (72.3) | 62 (74.7) | 0.67 |
| Dyslipidaemia, n (%) | 181 (51.1) | 142 (52.4) | 39 (47.0) | 0.38 |
| Previous stroke, n (%) | 16 (4.5) | 14 (5.2) | 2 (2.4) | 0.29 |
| Previous ischemic heart disease, n (%) | 35 (9.9) | 26 (9.6) | 9 (10.8) | 0.73 |
| Child-Pugh score | ||||
| A/B/C, n (%) | 287 (86.9)/40 (12.1)/3 (1.0) | |||
| Liver stiffness, mean kPa (SD)∗∗ | 23.6 (14.8) | 22.9 (13.8) | 33.9 (25.4) | 0.10 |
| CAP, mean dB/m (SD)∗∗∗ | 307.0 (58.0) | 308.1 (57.6) | 281.3 (77.6) | 0.43 |
Hypertension: ≥140/90 mmHg or requiring treatment; type 2 diabetes: as a fasting plasma glucose ≥126 mg/dl or a non-fasting plasma glucose ≥180 mg/dl or requiring treatment.; dyslipidemia: serum triglycerides ≥150 mg/dl and/or total cholesterol >200 mg/dl, LDL >130 mg/dl, HDL<40 mg/dl in men and <50 mg/dl in women or requiring treatment.
Continuous variables were compared using t test or Wilcoxon rank-sum, depending on the normality of their distribution. Categorical variables were compared using the chi-square test. A p <0.05 was considered statistically significant.
CAP, controlled attenuation parameter; T2D, type 2 diabetes.
Alcohol intake was defined as <20 g/day and <30 g/day for women and men, respectively.
Data available in 83 individuals.
Data available in 75 individuals.