Figure 3.

RPE morphology in normal and AMD-affected donors. RPE cells from four different donors imaged at the perifovea using 488-nm excitation and capturing the autofluorescence emission signal. Top row: representatives of the unaffected perifovea from a healthy young (36 years) and healthy aged (90 years) donor. In both, the polygonal patterns can be identified. Healthy young RPE cells tend to be smaller and on visual inspection less autofluorescent. Bottom row: the perifovea of two AMD-affected donors (left, 86 years; right, 84 years). In AMD, RPE cell delineation is difficult and RPE cells tend to be enlarged. Scale bar: 10 µm.