Figure 4.

Cell shape descriptors. Shape descriptors of six exemplary perifoveal RPE cells from two donors (AMD [84 years old] and unremarkable macula [90 years old]). The black shapes contour the outline of the RPE cells. In green, blue, and red are the best-fitting ellipse, circle, and square, respectively. Healthy-aged RPE cells are almost uniformly hexagonal. In AMD, RPE cells seem elongated and dysmorphic. Shape descriptors of RPE cells in AMD show lower values in solidity, roundness, and form factor, all associated with AMD.