Fig. 7. TEM image of cellular uptake mechanism of Au-OPEG-CTX NCs by MDA-MB-468 cells. (a) First step is a clathrin-mediated interaction of nanoparticles with cell membrane, (b) which triggers the formation of an early endosome, (c) followed by internalization of the nanoparticle into the mature endosome. (d) Next step is the accumulation of clusters of nanoparticles in endosomes, (e and f) progressively evolving to lysosomes.
