Figure 6.

Expression of metabolic genes in livers of a nonhuman primate polycystic ovary syndrome model. Relative expression of Arntl1/Bmal1 (brain and muscle arntl-like 1) and Clock (clock circadian regulator), Hmgcs2 (3-hydroxy-3-methylglutaryl-CoA synthase 2), Ddit3 (DNA damage inducible transcript 3), Fgf21 (fibroblast growth factor 21), Mogat1 (monoacylglycerol O-acyltransferase 1), and Ppar-γ (proliferator-activated receptor gamma) messenger RNA levels by quantitative real-time polymerase chain reaction in livers isolated from female rhesus macaques treated with control (cholesterol implants) or testosterone implants for 5 years. Data are displayed as means ± SE of the mean (n = 10 animals/ treatment) and normalized to Rpl32. *P ≤ 0.05 for Clock, Hmgcs2, and Fgf21; **P ≤ 0.01 for Arntl/Bmal1, Ddit3, Mogat1, and Ppar-γ vs control using Student’s t-test.