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| BC feature | Effect |
|---|---|
| Negative surface charge/artificial BC | Reduced immune system recognition due to limited interaction with plasma membrane60 |
| Size increase/aggregation | Immune clearance42,60 |
| Opsonins enrichment | Phagocytosis61,62 |
| Protein conformational changes | Inflammatory response triggering,63 amyloid fibrils formation, autoimmunity64,65 |
