Table 2.

Descriptive Statistical Summary of Total Levothyroxine Pharmacokinetic Parameters (Baseline Adjusted)

Parameter, unit	Treatment
	A (15 minutes)					B (30 minutes)
	N	Arithmetic		Geometric		N	Arithmetic		Geometric
		Mean	CV%	Mean	CV%		Mean	CV%	Mean	CV%
AUC0–48, h × ng/mL	33	1141.19	29.22	1093.48	30.77	33	1239.97	22.25	1210.13	22.89
AUC0–72, h × ng/mL	32	1622.86	27.14	1565.75	27.81	33	1724.83	21.83	1684.38	22.64
Cmax, ng/mL	33	44.80	32.30	42.50	34.74	33	51.80	26.09	50.00	28.15
tmax,a hours	33	1.486 (0.985, 7.980)				33	1.486 (0.985, 5.987)

^a Median (min, max) presented for t_max.

Treatment (A): levothyroxine sodium 4 mL × 150 mcg/mL oral solution, 15 minutes before breakfast.

Treatment (B): levothyroxine sodium 4 mL × 150 mcg/mL oral solution, 30 minutes before breakfast.

AUC, area under the curve; CV, coefficient of variation; Max, maximum; Min, minimum; N, number of observations.