. 2022 Aug 9;32(8):897–904. doi: 10.1089/thy.2021.0604

Table 3.

Summary of Geometric Mean Ratios (Treatment A/Treatment B) and 90% Confidence Intervals for Comparison of Levothyroxine Administration at 15 and 30 Minutes (Baseline-Adjusted Data)

Parameter, unit	Geometric LSM		GMR,^a %	90% CI^b		Intrasubject CV, %
Parameter, unit	Treatment A, 15 minutes	Treatment B, 30 minutes	GMR,^a %	Lower, %	Upper, %	Intrasubject CV, %
AUC_0–48, h × ng/mL	1087.85	1209.44	89.95	85.85	94.24	11.19
AUC_0–72, h × ng/mL	1551.95	1693.93	91.62	86.50	97.04	13.60
C_max, ng/mL	42.29	49.97	84.64	79.98	89.58	13.64

^{^a}

Geometric mean ratio.

^{^b}

Ninety percent confidence interval for the GMR.

Treatment (A): levothyroxine sodium 4 mL × 150 mcg/mL oral solution, 15 minutes before breakfast.

Treatment (B): levothyroxine sodium 4 mL × 150 mcg/mL oral solution, 30 minutes before breakfast.

LSM, least squares mean.