Table 4.

Summary of Possibly Related Adverse Events by Treatment

System organ class/MedDRA® preferred term	Treatment group
	A, 15 minutes	B, 30 minutes
Number of subjects dosed	35	34
Gastrointestinal disorders
Vomiting	0	1 (2.9%)
Investigations
Blood pressure increased	1 (2.9%)	0
Body temperature increased	0	1 (2.9%)
Nervous system disorders
Headache	2 (5.7%)	1 (2.9%)
SAEs	0	0

Treatment (A): levothyroxine sodium 4 mL × 150 mcg/mL oral solution, 15 minutes before breakfast.

Treatment (B): levothyroxine sodium 4 mL × 150 mcg/mL oral solution, 30 minutes before breakfast.

MedDRA^®, Medical Dictionary for Regulatory Activities, version 23.0; SAEs, significant adverse events.