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. 2022 Mar 8;145(8):2869–2881. doi: 10.1093/brain/awac093

Figure 4.

Figure 4

Alzheimer’s disease cases showed higher pathological load in the NbM but not lower ChAT cell density compared to controls. Alzheimer’s disease donors had significantly higher amyloid-β (P = 0.002) and p-tau (P = 0.0002) load as shown in A and B. However, ChAT cell density did not differ to controls, as shown in C. Of note, some Alzheimer’s disease donors had very little ChAT cell density, while others had similar counts to controls, illustrating the heterogeneity in our Alzheimer’s disease cohort. Pathology inserts show the immunoreactivity of amyloid-β (Aβ) (A), p-tau (B) and ChAT (C). AD = Alzheimer’s disease; p-tau = phosphorylated-tau. **P < 0.01. ***P < 0.001.