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. 2022 Aug 27;13(8):740. doi: 10.1038/s41419-022-05175-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A, B The colony-formation ability of SHG-44 and A172 glioma cells was decreased after knocking down circKIF4A, which was reversed after supplementation with miR-335-5p mimics. C, D EdU assay was conducted. The proliferation rate was also rescued after transfecting with miR-335-5p mimics when circKIF4A was inhibited in SHG-44 glioma cell lines. E, F The glucose uptake rate and lactate production speed were reduced after knockdown of circKIF4A, which was reversed by transfection of miR-335-5p mimics. G The expression of ALDOA protein was lower in the circKIF4A knockdown group in the mouse xenograft experiments. H Western blot assay showing that ALDOA was decreased after the suppression of circKIF4A in SHG-44 and A172 glioma cell lines. I Western blot assays revealed that the reduction in ALDOA was rescued by supplementation with miR-335-5p mimics. **p < 0.01. The experiment was repeated three times independently.