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. 2022 Aug 27;8:375. doi: 10.1038/s41420-022-01166-3

Fig. 2. NETosis inhibition, NETs depletion and degradation alleviate SI-ALI.

Fig. 2

NETosis inhibition by PAD4 inhibitor, NETs depletion by anti-Ly6G and NETs degradation by DNase I protects against lung injury induced by CLP. A H&E staining of the lung tissues. Scale bar: 50 µm. B Semiquantitative histological scores of lung injury in groups (n = 6). C The lung wet/dry ratio (n = 6). D The levels of cf-DNA and (E) TNF-α, IL-1β, and IL-6 in plasma (n = 6). F The levels of TNF-α, IL-1β, and IL-6 in BALF (n = 6). Each bar shows means ± SEM. The comparison between two groups was performed using unpaired t-test. **p < 0.01 versus the sham group; ##p < 0.01 versus the saline group.