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Evolution of tacrolimus trough concentrations (Ctrough) during and after nirmatrelvir-ritonavir administration. A total of 10 patients received nirmatrelvir-ritonavir 12 hours after the last dose of tacrolimus for a period of 5 days (D1–D5). Tacrolimus was restarted at the initial dose on D7. Tacrolimus Ctrough increased >10 ng/ml for 3 patients (#2, 3, and 6), so the dosage was adjusted after D9 for these patients. #, number; D, day.
