Table 2.

Summary of experimental studies on the effects of inflammation on the central nervous system

Author(s)	Year	Model	Conclusion
Rashid et al.	2021	UTI in mice Readout: behavioral and structural brain dysfunction	Mice with UTI demonstrated impairments of the frontal cortex and hippocampus, which were reversed following treatment with systemic anti-IL-6 antibody
An-HsunChou et al.	2014	60 min bilateral ischemia reperfusion injury-induced AKI Study endpoint/s: 2 and 24 h Readout: cDNA based microarray	Mice with AKI exhibited upregulated mRNA levels of genes involved in inflammation
Salama et al.	2013	Bilateral renal ischemia reperfusion injury in rats Readout: TLR-4 expression	↑ TLR-4 expression within hippocampus and striatum
Liu et al.	2008	60 min bilateral ischemia reperfusion injury-induced AKI Study endpoint: 24 h Readout: Histology	↑ Neuronal pyknosis and microgliosis ↑ Keratinocyte-derived chemoattractant and G-CSF in the cerebral cortex and hippocampus ↑ Expression of glial fibrillary acidic protein in astrocytes in the cortex and corpus callosum
Adachi et al.	2001	Bilateral rat renal artery occlusion. Endpoint: 48 h Readout: motor activity and brain monoamine turnover	↓ Turnover of DA in the striatum, mesencephalon and hypothalamus Impaired motor activity

UTI, urinary tract infection; cDNA, complementary deoxyribonucleic acid; TLR-4, toll-like receptor-4; AKI, acute kidney injury; IL-6, interleukin-6; mRNA, messenger RNA; G-CSF, granulocyte colony-stimulating factor; and DA, dopamine