Preparation and schematic diagram of CSMA, MSN-SF/CS, MSN-SF/CS microsphere and multifunctional biohybrid microsphere system. A Diagram of the preparation process of MSN-SF/CS drug-loaded microspheres. Reproduced with permission from Ref. [197]. Copyright 2022, Elsevier. B Schematic illustration of the fabrication of multifunctional biohybrid microsphere system and its application in chronic wound healing. (a) Microspheres were designed to isolate bFGF protein which was produced using E. coli expression system. (b–c) Conjugated with bFGF, the biohybrid microspheres were applied for enhanced wound healing in diabetic mice. Reproduced with permission from Ref. [68]. Copyright 2021, Elsevier. C Schematic diagram of the fabrication of CSMA microspheres and their application in wound healing. Reproduced with permission from Ref. [196]. Copyright 2022, Springer. D Antibacterial schematic diagram of MSN-SF/CS microspheres. Reproduced with permission from Ref. [197]. Copyright 2022, Elsevier.