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Diagnostic assays and viral biomarkers in HPV-related HNSCCs identification
Concepts for possible diagnostic algorithms to identify HPV-driven HNSCC using a combination of direct (HPVDNA + E6*I mRNA/E6-E7 mRNA) and surrogate cellular markers (p16INK4a) of oncogenic HPV infection in fresh and FFPE tissues (lower panel). HPV-biomarkers in body fluids used in combination with diagnostic algorithm for early diagnosis and follow-up of HNSCCs (upper panel).
