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ADME properties of the selected compounds predicted by SwissADME
| Compound | GIAa | BBBPb | CYP1A2 inhibitor | CYP2C19 inhibitor | CYP2C9 inhibitor | CYP2D6 inhibitor | CYP3A4 inhibitor | Lipinski | Log S |
|---|---|---|---|---|---|---|---|---|---|
| ZINC61991204 | Low | No | No | No | No | No | No | Yes | − 3.20 |
| ZINC67910260 | Low | No | No | No | No | No | Yes | Yes | − 6.58 |
| ZINC61991203 | Low | No | No | No | No | No | No | Yes | − 5.66 |
| ZINC08790293 | Low | No | No | No | No | No | Yes | Yes | − 5.54 |
aGastrointestinal absorption
bBlood-brain barrier permanent
