Figure 1.

Pseudovirus bearing the Omicron spike protein efficiently infects cells expressing mACE2

(A) 293T cells were transfected with ACE2 expression plasmids of 10 species and then infected by lentiviral pseudoparticles bearing the spike protein of either the Wuhan SARS-CoV-2 variant or the Omicron variant. Infected cells would be GFP positive (green). Blue dye-stained nuclei. Images shown here are representatives of two independent experiments.

(B) A similar experiment was performed as in (A), except pseudoviruses expressing firefly luciferase were employed.

(C) Infection of hACE2-and mACE2 stable 293T cells by pseudoviruses bearing the spike protein of either the Wuhan SARS-CoV-2 variant or the Omicron variant.

Results in each bar graph contain at least three technical replicates.