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. 2022 Aug 29;40(11):111359. doi: 10.1016/j.celrep.2022.111359

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Omicron bearing WA1 spike is attenuated in K18-hACE2 mice

(A) Body weight loss of K18 mice after infection with 10⁴ PFUs of Omicron-WA1 S, WA1-Omicron 5′ UTR-Nsp12, or Omicron or 10³ PFUs WA1.

(B) Survival curves after infection. Numbers of mice in each group are indicated in the legend.

(C and D) sgmRNA (C) and viral RNA (D) levels in NBs at 2 DPI.

(E and F) sgmRNA (E) and viral RNA (F) levels from brains at 6 DPI.

(G) Infectious virus titers from lungs at 6 DPI. ^∗p < 0.05.

Results shown in this figure were derived from one experiment. Each solid shape represents one animal in (C)–(G).