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. 2022 Aug 24;21:216–224. doi: 10.1016/j.reth.2022.07.002

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© 2022 The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 3 — hUCMSC-Ex prevented endothelial cell apoptosis in papain-treated lungs. (A) Representative TUNEL results using lung sections from each group. Increased TUNEL-positive endothelial cells were observed in the Papain group. hUCMSC-Ex reduced TUNEL-positive endothelial cells. Magnification, ×400; scale bar, 50 μm. Quantitative results showed percentage of TUNEL-positive cells in the three groups. Data are presented as mean ± SEM. ∗∗∗P < 0.001 compared with the Control group, ^###P < 0.001 compared with the Papain group. n = 3. (B) The expression of active caspase-3 was determined by western blotting. hUCMSC-Ex repressed enhanced active caspase-3 activity in the model group.