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. 2022 Aug 24;21:216–224. doi: 10.1016/j.reth.2022.07.002

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 5 — Several miRNAs may be involved in the protective effects of hUCMSC-Ex in papain-induced emphysema. (A) miRNA-seq showed that 108 miRNAs were up-regulated and 231 miRNAs were down-regulated in hUCMSC-Ex. Volcano plot graphs of differentially expressed genes (as assessed by the –log10 (padj)). (B) Significant Target gene network prediction of the top 10 miRNAs. (C) The result of transcriptome analysis showed that the top 10 miRNA-related target genes were enriched according to the KEGG annotations. (D) GO analysis of the top 10 miRNA-related target genes show that the overrepresented biological processes (P values: Benjamini-Hochberg corrected).