Table 2.

Summary of WMH predictors of treatment outcome.

Region	Baseline Association Treatment	Longitudinal Changes with Treatment
Deep	Strong evidence for association between lower deep WMH burden and positive treatment outcome in LLD, age effects may be important	None reported.
Periventricular	Moderate evidence for association between lower deep WMH burden and positive treatment outcome in LLD	None reported.
Whole-brain	Weak evidence for association between lower global WMH burden and positive treatment outcome in LLD, most studies report none	Weak evidence for increases in non-responders in LLD.