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. 2022 Aug 15;13:898955. doi: 10.3389/fphar.2022.898955

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Copyright © 2022 Hong, Lu, Wu, Chen, Chen, Zhang, Huang and Cui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects and mechanisms of paeoniflorin on pain. Administration of paeoniflorin may relieve pain induced by colorectal distention partial sciatic nerve ligation, or paclitaxel. Mechanisms such as adenosine A1 and opioid receptor activation, induction of microglial SOCS3 expression, and inhibition of neutrophil infiltration, NF-κB transcription, NLPR3 inflammasome activation, microglial MMP-9/2 activity, ASK1 inhibition, and p38 inhibition may mediate the analgesic effect of paeoniflorin.