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. 2022 Aug 15;13:898955. doi: 10.3389/fphar.2022.898955

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Copyright © 2022 Hong, Lu, Wu, Chen, Chen, Zhang, Huang and Cui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects and mechanisms of paeoniflorin in glioma. Paeoniflorin administration can suppress glioma growth by promoting STAT3 degradation and de-phosphorylation of STAT3 and inhibiting epithelial-to-mesenchymal transition. Increasing the expression of miR-16 is another mechanism for the anti-glioma effect of paeoniflorin. The increased miR-16 upon paeoniflorin treatment induces glioma cell apoptosis by down-regulating MMP-9 expression.