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. 2022 Aug 15;9:912887. doi: 10.3389/fmolb.2022.912887

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Copyright © 2022 Gelbach, Zhang, Kwon, Bates, Farmer, Dordick, Wang and Linhardt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sensorgrams and bar graphs (based on triplicate experiments with standard deviation) of normalized SGP-RBD binding to immobilized surface heparin; SGP-RBD was mixed with chemically modified heparins (2-O-desulfated, N-desulfated, and 6-O-desulfated) in solution prior to injection in direct binding competition with the surface heparin (A) WT; (B) Delta; (C) Omicron; (D) WT; (E) Delta; (F) Omicron.