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. 2022 Aug 15;13:900961. doi: 10.3389/fphys.2022.900961

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Copyright © 2022 Wang, You, Ren, Zhu, Mao, Liang, Wang, Guo, Liu and Xue.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Finasteride alleviated inflammation and restored intestinal tight junction by reducing TMAO level. After sacrifice, colon tissues were collected for paraffin section preparation. (A) Colon sections were stained with Hematoxylin-eosin staining. The yellow arrow indicated the inflammatory cell infiltration in the BSA + HFD group. (B) Immunofluorescence staining of Claudin-1 and Zo-1 were performed. Scale bar: 50 μm. (C) qRT-PCR analyses of Claudin-1 and Zo-1 mRNA expression in the colon tissue were performed. After normalization against β-actin, the relative abundance of Claudin-1 and Zo-1mRNA levels were calculated and presented as fold changes. All data were expressed as the mean ± SD (n = 6) and subjected to one-way ANOVA followed by the Bonferroni post hoc test. ^* p < 0.05 vs. Ctrl group, ^# p < 0.05 vs. BSA + HFD group.