Table 2.
Subchondral Bone MRI Biomarkers Compared Between OA and Control Groups, With Statistical Significance Labeled.
| Subchondral Bone MRI | OA |
Control |
OA vs. Control |
||||
|---|---|---|---|---|---|---|---|
| Maximum | Minimum | Median | Maximum | Minimum | Median | P Value | |
| BV/TV (%) | |||||||
| Femur | |||||||
| Medial | 44.30 | 26.60 | 35.10 | 46.30 | 29.00 | 39.10 | <0.01 |
| Lateral | 47.80 | 31.10 | 36.20 | 46.20 | 32.80 | 39.00 | <0.05 |
| Tibia | |||||||
| Medial | 56.20 | 37.40 | 43.20 | 49.70 | 30.20 | 37.40 | <0.01 |
| Lateral | 41.20 | 31.00 | 36.00 | 56.10 | 42.20 | 46.70 | <0.01 |
| TbTh_mean (µm) | |||||||
| Femur | |||||||
| Medial | 340.00 | 265.00 | 274.00 | 369.00 | 271.00 | 286.00 | <0.01 |
| Lateral | 306.00 | 266.00 | 279.00 | 340.00 | 269.00 | 278.00 | 0.63 |
| Tibia | |||||||
| Medial | 362.00 | 256.00 | 269.00 | 360.00 | 264.00 | 274.00 | 0.69 |
| Lateral | 301.00 | 262.00 | 275.00 | 356.00 | 262.00 | 278.00 | 0.32 |
| TbSp_mean (µm) | |||||||
| Femur | |||||||
| Medial | 427.00 | 316.00 | 372.00 | 454.00 | 313.00 | 353.00 | 0.43 |
| Lateral | 435.00 | 299.00 | 356.00 | 428.00 | 294.00 | 341.00 | 0.14 |
| Tibia | |||||||
| Medial | 353.00 | 266.00 | 296.00 | 456.00 | 312.00 | 368.00 | <0.01 |
| Lateral | 471.00 | 320.00 | 368.00 | 314.00 | 258.00 | 293.00 | <0.01 |
| TbN (mm−1) | |||||||
| Femur | |||||||
| Medial | 1.46 | 0.95 | 1.26 | 1.55 | 1.04 | 1.38 | <0.05 |
| Lateral | 1.70 | 1.12 | 1.28 | 1.68 | 1.17 | 1.40 | <0.05 |
| Tibia | |||||||
| Medial | 2.16 | 1.30 | 1.58 | 1.51 | 1.11 | 1.37 | <0.01 |
| Lateral | 1.44 | 1.12 | 1.29 | 2.02 | 1.51 | 1.67 | <0.01 |
| D2D (a.u) | |||||||
| Femur | |||||||
| Medial | 1.59 | 1.40 | 1.53 | 1.63 | 1.37 | 1.53 | 0.73 |
| Lateral | 1.56 | 1.33 | 1.50 | 1.62 | 1.45 | 1.55 | <0.01 |
| Tibia | |||||||
| Medial | 1.61 | 1.10 | 1.49 | 1.57 | 1.37 | 1.49 | 0.9 |
| Lateral | 1.57 | 1.32 | 1.49 | 1.59 | 1.43 | 1.48 | 0.41 |
| D3D (a.u) | |||||||
| Femur | |||||||
| Medial | 2.13 | 2.02 | 2.07 | 2.14 | 1.99 | 2.09 | 0.19 |
| Lateral | 2.13 | 2.00 | 2.09 | 2.15 | 2.06 | 2.12 | <0.05 |
| Tibia | |||||||
| Medial | 2.16 | 1.74 | 2.03 | 2.11 | 1.94 | 2.07 | <0.05 |
| Lateral | 2.10 | 1.97 | 2.06 | 2.16 | 1.91 | 2.06 | 0.99 |
| QTS (a.u) | |||||||
| Femur | |||||||
| Medial | 3.47 | 0.95 | 1.81 | 3.35 | 1.26 | 2.41 | <0.01 |
| Lateral | 3.03 | 1.35 | 2.03 | 3.31 | 1.68 | 2.35 | <0.05 |
| Tibia | |||||||
| Medial | 4.46 | 1.69 | 2.68 | 4.13 | 1.15 | 2.05 | <0.05 |
| Lateral | 2.65 | 1.27 | 1.88 | 4.48 | 2.40 | 3.00 | <0.01 |
MRI = magnetic resonance imaging; OA = osteoarthritis; BV/TV = bone volume to total volume fraction; QTS = quality of trabecular score; TbTh = trabecular thickness; TbSp = trabecular spacing; TbN = trabecular number; D2D = two dimensional fractal dimension measurements; D3D = three dimensional fractal dimension measurements.