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. 2022 Aug 15;12:905653. doi: 10.3389/fcimb.2022.905653

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Copyright © 2022 Nie, Wang, Huang, Yang, Gong, Feng and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SparCC analysis of the co-occurrence network and core microbiome. (A) Key species network in tumor tissue, paracancerous tissue, cancer surface, anatomically matched contralateral normal mucosa, saliva, and tongue coat. Each node represents a specie, and each edge represents a significant co-occurrence relationship. (B) SparCC network followed the law of power-law distribution. (C) Venn diagram depicts the overlap of bacterial species among the different niches. C, tumor tissue; PC, paracancerous tissue; CS, cancer surface; N, anatomically matched contralateral normal mucosa; S, saliva; T, tongue coat.