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. 2022 Aug 17;20:4481–4489. doi: 10.1016/j.csbj.2022.08.034

Fig. 4.

Fig. 4

The statistics of the AlphaFold2 models of 158 alanine insertion mutants of DHFRcoli. (a) The distribution of the RMSD values of the 158 AlphaFold2 models. (b) The comparison of the AlphaFold2 models’ RMSD values of experimentally foldable and unfoldable mutants. The statistical p value was calculated with the unpaired t-test. (c) The amounts of the foldable and unfoldable mutants in the Low RMSD group and the High RMSD group. The numbers beside the bar are the mutant number and the percentage in the corresponding group. (d) Scatter plot of the RMSD values of the 158 DHFRcoli alanine insertion mutants. The blue dots indicate the experimentally foldable mutants, and the orange dots indicate the unfoldable ones. (e) The correlation between RMSD values of the models, the foldability of the alanine insertion mutants, and the secondary structure units of the residues. The numbers in purple circles are the numbers of the alanine insertion mutants in different categories. (f) The correlation between the RMSD values of the AlphaFold2 models of the circular mutants and the alanine insertion mutants. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)