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. 2022 Aug 15;13:975185. doi: 10.3389/fgene.2022.975185

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Copyright © 2022 Zhang, Shi, Yi, Wang, Xia, Zhang, Jiang and Qi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The establishment of a risk signature for the TCGA dataset. (A) OS analysis utilizing univariate Cox regression for each of the 6 cuproptosis-associated genes with p < 0.3. (B) LASSO regression analysis of the six genes associated with OS. (C) Analysis of OS utilizing multivariate Cox regression for the six genes associated with OS. (D) Patients are classified according to their risk scores. (E) PCA plot for patients with LUAD depending on their risk scores. (F) Each patient’s survival probability (low- and high-risk groups are displayed on the left and right sides of the dotted line, respectively). (G) KM survival study of patients classified as having high or low risks. (H) ROC curves proved the risk score's predictive effectiveness. AUC, area under the ROC curve.