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. 2022 Aug 5;26:387–398. doi: 10.1016/j.omto.2022.08.004

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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b-AP15 inhibits cancer stemness via c-myc downregulation in UC cell lines

(A–D) RNA sequencing data from DMSO- or b-AP15-treated T24/R cells was analyzed via gene set enrichment analysis (GSEA). NES, normalized enrichment score. (E and F) The mRNA (E) expression or protein (F) expression of c-myc was determined via quantitative real-time PCR or immunoblotting (∗p < 0.05; ∗∗∗p < 0.001; #p < 0.0001). The cells were subjected to tumorsphere cultivation assay with or without a low-dose b-AP15 treatment (50 nM). (G and H) The results of this assay were presented as relative sphere numbers (G) and sphere diameters (H) (∗p < 0.05; ∗∗p < 0.01; #p < 0.0001).