FIGURE 3.

Drugs modulating the SGLT2 and its network. In the figure are presented known SGLT2 ligands ordered vertically by increasing enzyme inhibition constant Ki (nM) and half maximal inhibitory concentration IC50 (nM). Additionally, we included metformin, not targeting SGLT2 but regulating other components of its network. Ki reflects the binding affinity, the smaller the Ki, the greater the binding affinity, and the smaller amount of medication needed in order to inhibit the activity of that enzyme. IC50 reflects the functional strength of the inhibitor for a drug, is dependent on the enzyme concentration, and is always larger than Ki. Genes associated with specific key terms have blue labels.