Table 1.

Summary of advantages and disadvantages of different AP-MS-based approaches

	IP-MS	PD-MS
		Endogenous	Ectopic
			Transduction	Transfection
Depth	low-medium	high	high	high
Time	weeks to months	months	days to weeks	days to weeks
Cost	high	high	low	very low
Flexibility	high	low	medium	low
Domain-specific PPIs	not feasible	not feasible	feasible