Figure 12.

AMPK hyperactivation alleviated PNAHS in mice.A, Representative images showing liver sections stained with HE or oil red O from mice in the WT-PN group and WT-PN+GSK621 group (mice treated with GSK621, an activator of AMPK). B, Pathological scores for hepatic steatosis determined from oil red O sections in a blinded manner. C, TG levels in liver homogenates from mice in the WT-PN group and WT-PN+GSK621 group. D–F, Serum TBIL, ALT, and AST levels in mice from the WT-PN group and WT-PN+GSK621. G, Western blot analyses and densitometric quantification of various proteins of interest. The results are expressed as the mean ± standard deviation (n = 7). ∗P < .05; ∗∗P < .01; ∗∗∗P < .001.