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. 2022 May 26;14(3):669–692. doi: 10.1016/j.jcmgh.2022.05.008

Figure 9.

Figure 9

Akt2 hyperactivation abrogates the benefits of protein phosphatase-2A (PP2A) in mice given parenteral nutrition.A, Representative images showing liver sections stained with HE or oil red O from mice in the Ad-PP2A-PN group (mice transfected with Ppp2ca and given PN) and Ad-PP2A-PN+SC79 group (also treated with 20 mg/kg/week SC79, an activator of Akt). B, Pathological scores for hepatic steatosis determined from oil red O sections in a blinded manner. C, TG levels in liver homogenates from mice in the Ad-PP2A-PN and Ad-PP2A-PN+SC79 groups. D–E, Serum ALT and AST levels in mice from the Ad-PP2A-PN and Ad-PP2A-PN+SC79 groups. F, Western blot analyses and densitometric quantification of various proteins of interest. The results are expressed as the mean ± standard deviation (n = 7). ∗P < .05; ∗∗P < .01.