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. 2022 Jun 9;14(3):643–668.e1. doi: 10.1016/j.jcmgh.2022.06.001

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

CA-PKA mice show gastric mucosal maldevelopment and develop preneoplastic lesions.A–D, Images of 12-month-old normal control (A) and CA-PKA mouse (B) with abdominal enlargement (arrows). Gross morphology of normal control (C) and mutant stomach (D) with marked enlargement. E–M, Hematoxylin and eosin-stained images of the stomach from 6-week-old and 12-month-old control and CA-PKA mice. In 6-week-old and 12-month-old control corpus (E & H), parietal (arrow) and chief cells (arrowhead) are indicated. F, Six-week-old mutant corpus with remaining parietal (arrow), chief cells (asterisks), and mucous cell hyperplasia (arrowheads) is shown. G, Image shows infiltrating neutrophils in the CA-PKA corpus (arrows). I, Twelve-month-old CA-PKA corpus showing stromal expansion (arrowheads), cystic dysplasia with nuclear stratification (arrows), and lymphocytic infiltration (asterisks). J, Lymphocytic infiltration (arrowheads) in 12-month-old mutants. K, Antrum from a 12-month-old control mouse showing the neck (arrow) and base (arrowhead) of antral glands. L, Mutant antrum showing invading antral glands (arrows) and goblet cells (arrowheads). M, Goblet cells (arrowheads) in 12-month-old mutants. Scale bars = 50 μm.