Table 1.
Characteristics of Patients Listed for SLKT (Cohort 1)
| Characteristic | Overall N = 10,785 | Karnofsky A N = 2,083 | Karnofsky B N = 4,961 | Karnofsky C N = 3,741 | p-value |
|---|---|---|---|---|---|
|
| |||||
| Age, y, mean (SD) | 56.2 (9.4) | 56.3 (9.2) | 56.6 (9.2) | 55.4 (9.6) | <0.001 |
|
| |||||
| Male, % | 63.2 | 66.9 | 62.7 | 61.8 | <0.001 |
|
| |||||
| Race/ethnicity, % | |||||
| White | 60.8 | 58.3 | 60.4 | 62.7 | <0.001 |
| Black | 14.0 | 16.2 | 15.1 | 11.4 | |
| Hispanic | 19.5 | 18.3 | 19.0 | 21.0 | |
| Other | 5.6 | 7.2 | 5.5 | 4.9 | |
|
| |||||
| BMI, kg/m2, mean (SD) | 28.4 (5.9) | 28.4 (5.4) | 28.4 (5.9) | 28.5 (6.3) | 0.64 |
|
| |||||
| Diabetes, % | 46.3 | 48.5 | 48.6 | 42.1 | <0.001 |
|
| |||||
| Dialysis, % | 46.0 | 34.6 | 42.4 | 57.0 | <0.001 |
|
| |||||
| MELD score, mean (SD) | 24.6 (8.4) | 20.1 (6.1) | 22.3 (6.7) | 30.1 (8.7) | <0.001 |
|
| |||||
| Serum albumin, g/dL, mean (SD) | 3.1 (0.7) | 3.1 (0.7) | 3.1 (0.7) | 3.1 (0.8) | <0.001 |
|
| |||||
| Ascites, % | <0.001 | ||||
| Absent | 16.9 | 27.1 | 17.6 | 10.2 | |
| Slight | 42.8 | 49.1 | 45.7 | 35.6 | |
| Moderate | 40.2 | 23.7 | 36.6 | 54.2 | |
|
| |||||
| Hepatic encephalopathy, % | <0.001 | ||||
| None | 34.1 | 49.8 | 35.3 | 23.7 | |
| Grade 1–2 | 56.8 | 47.7 | 58.7 | 59.2 | |
| Grade 3–4 | 9.1 | 2.4 | 5.9 | 17.0 | |
|
| |||||
| Liver disease, % | <0.001 | ||||
| Alcohol | 23.1 | 16.5 | 21.5 | 28.9 | |
| Hepatitis C | 27.0 | 32.4 | 28.1 | 22.6 | |
| Alcohol/hepatitis C | 4.6 | 4.1 | 4.8 | 4.6 | |
| NASH/cryptogenic | 25.1 | 22.2 | 26.7 | 24.7 | |
| Autoimmune/cholestatic | 5.3 | 6.3 | 5.0 | 5.3 | |
| Other | 14.8 | 18.6 | 14.0 | 13.8 | |
|
| |||||
| Hepatocellular carcinoma, % | 5.2 | 7.9 | 5.9 | 2.8 | <0.001 |
Abbreviations:
BMI: Body mass index
MELD: Model for end-stage liver disease
NASH: Non-alcoholic steatohepatitis