Table 3.
Characteristics of SLKT Recipients (Cohort 2)
Characteristic | Overall N = 5,516 | Karnofsky A N = 661 | Karnofsky B N = 1,999 | Karnofsky C N = 2,856 | p-value |
---|---|---|---|---|---|
| |||||
Age, y, mean (SD) | 55.9 (9.8) | 55.7 (9.9) | 56.3 (9.6) | 55.7 (9.9) | 0.11 |
| |||||
Male, % | 64.6 | 67.3 | 66.2 | 62.9 | 0.02 |
| |||||
Race/ethnicity, % | |||||
White | 62.9 | 62.9 | 63.4 | 62.6 | <0.001 |
Black | 15.2 | 19.4 | 17.4 | 12.8 | |
Hispanic | 16.8 | 11.5 | 15.2 | 19.3 | |
Other | 5.0 | 6.2 | 4.1 | 5.4 | |
| |||||
BMI, kg/m2, mean (SD) | 27.7 (5.8) | 27.4 (5.2) | 27.6 (5.5) | 27.9 (6.1) | 0.10 |
| |||||
Diabetes, % | 42.4 | 39.5 | 45.0 | 41.4 | 0.01 |
| |||||
Dialysis, % | 69.2 | 58.5 | 63.1 | 76.0 | <0.001 |
| |||||
MELD score, mean (SD) | 29.3 (8.1) | 24.2 (6.3) | 26.0 (6.8) | 32.9 (7.8) | <0.001 |
| |||||
Serum albumin, g/dL, mean (SD) | 3.1 (0.8) | 3.2 (0.7) | 3.1 (0.7) | 3.1 (0.8) | 0.01 |
| |||||
Ascites, % | |||||
Absent | 17.2 | 30.4 | 21.4 | 11.2 | <0.001 |
Slight | 38.1 | 42.1 | 42.3 | 34.3 | |
Moderate | 44.1 | 26.2 | 36.1 | 54.0 | |
| |||||
Hepatic encephalopathy, % | |||||
None | 32.1 | 49.3 | 39.3 | 23.1 | <0.001 |
Grade 1–2 | 53.2 | 43.4 | 52.8 | 55.7 | |
Grade 3–4 | 14.2 | 5.9 | 7.8 | 20.6 | |
| |||||
Medical condition, % | |||||
Not hospitalized | 57.5 | 91.1 | 85.5 | 30.0 | <0.001 |
Hospitalized (not ICU) | 23.9 | 7.1 | 11.6 | 36.4 | |
Intensive care unit | 18.7 | 1.8 | 3.0 | 33.5 | |
| |||||
Liver disease, % | |||||
Alcohol | 20.5 | 14.1 | 17.8 | 23.8 | <0.001 |
Hepatitis C | 22.7 | 23.9 | 24.7 | 21.0 | |
Alcohol/hepatitis C | 4.0 | 2.7 | 3.8 | 4.4 | |
NASH/cryptogenic | 21.7 | 17.2 | 20.7 | 23.4 | |
Autoimmune/cholestatic | 4.4 | 3.2 | 3.9 | 5.1 | |
Other | 26.7 | 38.9 | 29.2 | 22.2 | |
| |||||
Hepatocellular carcinoma, % | 11.2 | 14.4 | 13.1 | 9.1 | <0.001 |
| |||||
Liver Donor risk index, mean (SD) | 1.53 (0.30) | 1.52 (0.29) | 1.53 (0.32) | 1.53 (0.29) | 0.40 |
| |||||
KDPI, mean (SD) | 0.36 (0.26) | 0.36 (0.25) | 0.37 (0.26) | 0.36 (0.260) | 0.1516 |
Abbreviations:
BMI: Body mass index
MELD: Model for end-stage liver disease
ICU: Intensive care unit
NASH: Non-alcoholic steatohepatitis
KDPI: Kidney donor profile index