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. 2022 Aug 29;54(3):373–381. doi: 10.1007/s11239-022-02687-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Time to Inhibition of TxB₂ Production, hours (N = 21). Values are significantly different at all timepoints. p-values were calculated by using mixed-effects, repeated-measure ANOVA model with sequence, period, and treatment as fixed effects and subject as a random effect. The time to cut-off was set as 24 h if the cutoff point was not achieved at 24 h post dose. The TxB₂ analysis was based on 21 subjects who had valid TxB₂ concentration data