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. 2022 Aug 9;65(16):11322–11339. doi: 10.1021/acs.jmedchem.2c00897

Scheme 6. 1,4-Addition and Reduction Transformations of Compounds 1a and 1b.

Scheme 6

Reactants and conditions: (a) H2, Pd/C (10 mol %), MeOH, H-Cube, rt, 30 min; (b) CeCl3·7H2O(1.0 equiv), then NaBH4 (1.0 equiv), DCM, MeOH, rt, 15 min; (c) NiCl2·6H2O (0.5 equiv), NaBH4 (5.0 equiv), DCM, MeOH, rt, 1.5 h; (d) pyrrolidine (1.5 equiv), EtOH, rt, 5 min.