Figure 5.

Proposed binding mode of compound 1 at the human GPR84 receptor Alphafold (AF-Q9NQS5-F1). The overall view of the ligand–receptor complex and the zoomed ligand binding site are on the left and right. The ligand and the amino acids are shown by orange and blue sticks, respectively. Hydrogen bonds, π–π, and cation−π interactions are in pink, cyan, and green dashed lines, respectively. A section of helix 7 was hidden for a clear view in the zoomed image. The 1,2,4-triazine ring is numbered.