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. 2022 Aug 10;65(16):11270–11290. doi: 10.1021/acs.jmedchem.2c00804

Table 4. Physicochemical Properties and Activity Data of 3,5,6-Trisubstituted 1,2,4-Triazines 21–25.

2.3.

2.3.

a

Logarithm of the partition coefficient for n-octanol/water (CLog P) was calculated using ChemDraw2019.

b

Negative log of the IC50 in molar (pIC50); guanosine 5′-O-[gammathio]triphosphate ([35S]GTPγS) assay. Data are expressed as mean ± standard error of the mean (SEM).

c

Ligand lipophilic efficiency (LLE) = pIC50 – CLog P; GLPG 1205(XII), pIC50 = 7.27 ± 0.04; NA, not applicable.