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. 2022 Aug 16;65(16):11340–11364. doi: 10.1021/acs.jmedchem.2c00911

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© 2022 The Authors. Published by American Chemical Society

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Functional characterization of a second series of retigabine derivatives with improved photostability (compound 25–28, 31, 59, 60, 67, 68). (A) Proposed mechanism for retigabine photo-oxidation. (B) Average FluxOR fluorescence signals obtained in Kv7.2/Kv7.3-transfected cells upon exposure to the indicated photostable compounds, each used at a concentration of 10 μM in comparison with retigabine (RET 10 μM; purple bar). * indicates values significantly different (p < 0.05) from respective control. (C) HPLC traces of retigabine (RET) and compound 60 at 550 nm after 3 h exposure to UV–visible light.