Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Aug 16;65(16):11340–11364. doi: 10.1021/acs.jmedchem.2c00911

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 The Authors. Published by American Chemical Society

Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Effect of retigabine (RET), RL-81, and compound 60 on Kv7.2/Kv7.3 currents. (A) Representative macroscopic current traces recorded from CHO cell expressing Kv7.2/Kv7.3 channels in response to the indicated voltage protocol before (left) and after (right) application of 1 μM RET, RL-81 and compound 60, as indicated. Current scale, 200 pA; time scale, 200 ms. (B,C) Dose–response curves reporting the effects of the 3 indicated compounds on the V_1/2 shift (ΔV_1/2) in mV (B) and on maximal current density (I_drug/I_control; C) calculated at +20 mV for Kv7.2/Kv7.3 channels. (D,E) Current density of the indicated homomeric Kv7.2 channels (D) and the effect of 10 μM RET or 1 μM 60 on the indicated homomeric Kv7.2 mutant channels. * indicates values significantly different (p < 0.05) from respective controls.