Table 5. SAR around 15^e.

^aGI₅₀ values are shown as the median and median absolute deviation (MAD) of at least two independent experiments performed in triplicate.

^bIC₅₀ was determined by following the biochemical kinase assay protocol. The data represent the mean and standard deviation of at least two independent experiments performed in duplicate.

^cOverall smallest toxic dose.

^dData taken from ref (52).

^eCell viability in the presence of varying concentrations of compounds was measured by the AlamarBlue assay. HMVEC-Cs were treated with inhibitors, and GI₅₀ values were measured to assess the vasculotoxicity as the AUC (area under the curve) as shown in Figure 6a. ND, no inhibition detected at concentrations of ≤10 μM.