Table 3.

Fluoxetine versus another anti-obesity agents and no treatment

Comparison	Mean difference (95% CI)	Trials	Participants
Weight loss
Fluoxetine 60 mg/day versus sibutramine	4.3 kg (−3.2–11.8); p = 0.26	1	17
Fluoxetine 60 mg/day versus metformin	−8.9 kg (−19.9–2.1); p = 0.11	1	17
Fluoxetine 20 mg/day versus sibutramine	7 kg (4.4–9.6); p = 0.0001*	1	61
Fluoxetine 20 mg/day versus dexfenfluramine	−0.5 kg (−3.4–2.4); p = 0.73	1	58
Fluoxetine 20 mg/day versus diethylpropion	7.5 kg (4.7–10.3); p = 0.0001*	1	61
Fluoxetine 20 mg/day versus fenproporex	5.3 kg (2.4–8.2); p = 0.0004*	1	62
Fluoxetine 20 mg/day versus mazindol	4.9 kg (2.6–7.3); p = 0.0001*	1	60
Fluoxetine 60 mg/day versus no treatment	−2.7 kg (−3 to −2.4); p = 0.0001*	1	60

	Mean difference (95% CI)
BMI reduction
Fluoxetine 60 mg/day versus sibutramine	−1.5 kg/m2 (−5.2–2.2); p = 0.42	1	17
Fluoxetine 60 mg/day versus metformin	−2.2 kg/m2 (−8.4–4); p = 0.48	1	17
Fluoxetine 20 mg/day versus sibutramine	2.4 kg/m2 (1.4–3.4); p = 0.0001 *	1	61
Fluoxetine 20 mg/day versus diethylpropion	2.9 kg/m2 (1.8–4); p = 0.0001 *	1	61
Fluoxetine 20 mg/day versus fenproporex	2 kg/m2 (0.9–3.1); p = 0.0006*	1	62
Fluoxetine 20 mg/day versus mazindol	2 kg/m2 (1.1–2.9); p = 0.0001*	1	60
Fluoxetine 60 mg/day versus no treatment	−0.5 kg/m2 (−0.6 to −0.3); p = 0.0001 *	1	60

	Relative risk (95% CI)
Adverse events
Fluoxetine 60 mg/day versus sibutramine	1.19 (0.75–1.88); p = 0.47	1	17
Fluoxetine 60 mg/day versus metformin	1.78 (0.86–3.69); p = 0.12	1	17
Fluoxetine 20 mg/day versus sibutramine	1.58 (0.91–2.77); p = 0.11	1	61
Fluoxetine 20 mg/day versus dexfenfluramine	1.09 (0.89–1.33): p = 0.42	1	59
Fluoxetine 20 mg/day versus diethylpropion	1.58 (0.91–2.77); p = 0.11	1	61
Fluoxetine 20 mg/day versus fenproporex	1.20 (0.75–1.92); p = 0.45	1	62
Fluoxetine 20 mg/day versus mazindol	1.05 (0.68–1.64); p = 0.82	1	60
Fluoxetine 60 mg/day versus no treatment	8.67 (2.94–25.94); p = 0.0001 *	1	60

^*p value ≤0.05.